产品货号：
Z20095
中文名称：
MCL1抗体
英文名称：
Anti-MCL1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MCL1 Antibody |
| 指标别名 | EAT;Mcl 1;Mcl 1l;Mcl 1s Delta TM;MCL1;mcl1/EAT;MCL1L;MCL1S;TM |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | MCL1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human MCL1(303-325aa RDWLVKQRGWDGFVEFFHVEDLE),different from the related mouse sequence by one amino acid. |
| 实际分子量 | 37KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BCL2L3,also known as MCL1(myeloid cell leukemia sequence 1) encodes an anti-apoptotic protein,which is a member of the Bcl-2 family.Alternative splicing results in multiple transcript variants.The longest gene product(isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products(isoform 2 and isoform 3) promote apoptosis and are death-inducing.Using the methods of somatic cell hybrid analysis and fluorescence in situ hybridization),the MCL1 gene is mapped to human 1q21.MCL1is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors.Phosphorylation of MCL1 directs its interaction with the tumor suppressor protein FBW7,which is the substrate-binding component of a ubiquitin ligase complex.The polyubiquitylation of MCL1 then targets it for proteasomal degradation.The degradation of MCL1 was blocked in patient-derived tumor cells that lacked FBW7 or had loss-of-function mutations in FBW7,conferring resistance to antitubulin agents and promoting chemotherapeutic-induced polyploidy. |
| Uniprot ID | Q07820 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | myeloid cell leukemia sequence 1(BCL2-related) |
| 蛋白名全称 | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：MCL1抗体，MCL1多抗，Anti-MCL1 Antibody